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Document 3173
DOCN M94A3173
TI Phylogenetic analysis of HTLV-I/II from Colombia, Chile and Ghana.
DT 9412
AU Miura T; Zaninovic V; Cartier L; Osei-Kwasi M; Aysi NK; Tajima K; Sonoda
S; Yamashita M; Igarashi T; Takehisa J; et al; Inst. for Virus Res.,
Kyoto Univ., Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):136 (abstract no. PA0163). Unique
Identifier : AIDSLINE ICA10/94369402
AB OBJECTIVE: To clarify the phylogenetic relation of HTLV in the world,
some new isolates of HTLV-I/II from Colombia, Chile and Ghana were
genetically analyzed and compared with other HTLV/STLV. METHODS:
Phylogenetic tree was constructed from nucleotide sequence of the part
of LTR amplified by PCR. RESULTS: All 8 isolates (7 Colombia and 1
Chile) of HTLV-I from native inhabitants in South America belonged to
subtype A in cosmopolitan type, which consisted of many Caribbean and
some Japanese and Indian isolates. All 3 isolates from Ghana belonged to
subtype C which consisted of West African and some Caribbean isolates.
All 8 isolates of HTLV-II from native South American (7 Colombia and 1
Chile) belonged to HTLV-IIb. HTLV-II from a native Ghanaian in West
Africa belonged to HTLV-IIa. DISCUSSION AND CONCLUSIONS: Subtype A
implied a connection of the native Caribbean and South American with
Japanese and Indian, a possible migration of the lineage to the American
continent via Beringia in the paleolithic period, or across the Pacific
Ocean in the more recent time. Subtype C supported the connection
between Caribbean and West Africa during the slave trade. HTLV-IIb was
suggested to be endemic in native inhabitant of South America, while
there is a possibility that HTLV-IIa is endemic in Africa although
getting conclusion is premature.
DE Chile Colombia Comparative Study Ghana Human
HTLV-I/CLASSIFICATION/*GENETICS/ISOLATION & PURIF HTLV-I
Infections/MICROBIOLOGY HTLV-II/CLASSIFICATION/*GENETICS/ISOLATION &
PURIF HTLV-II Infections/MICROBIOLOGY *Phylogeny Polymerase Chain
Reaction/METHODS Repetitive Sequences, Nucleic Acid MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).